Day One

Explore the Agenda

Monday, July 29

Tuesday, July 30

7:15 am Morning Check-in & Coffee

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8:15 am Chair’s Opening Remarks

Nicholas Valiante

Co-Founder & Chief Scientific Officer, Innovac Therapeutics

8:30 am CXOs’ Panel Discussion: Unlocking the Next Frontiers of mRNA-Based Vaccines & Therapeutics to Ensure Better Drugs Reach Patients Faster

Nicholas Valiante

Co-Founder & Chief Scientific Officer, Innovac Therapeutics

Thaminda Ramanayake

Chief Business Officer, CureVac

Nathaniel Wang

Chief Executive Officer, Replicate Bioscience

Sophia Lugo

CEO, Radar Therapeutics

Igor Matushansky

Chief Medical Officer, Sail Biomedicines

Andrew Allen

Chief Executive Officer, Gritstone Bio

What do you think are the top 3 opportunities/near future wins for the mRNA field?
Given your role in the C-suite, what are the biggest challenges you face on a day-to-day basis and what kind of decisions do you have to make?
Given your role and affiliation, how do you view the market consolidation and how does it affect your day-to-day and decision making?
What are your views on the investor climate and partnership strategies or opportunities for collaboration in the mRNA field this year?

9:30 am Clinical Safety & Impact of RNA Cell Therapy in Patients with Myasthenia Gravis

Christopher Jewell

Chief Scientific Officer, Cartesian Therapeutics

RNA cell therapy allows transient expression of chimeric antigen receptor in T cells, enabling therapies that do not require lymphodepletion and
eliminate risk of cancerous transformation
Expanding the potential of cell therapies to patients with autoimmunity, where the risk-benefit ratio is more stringent than in oncology
Sharing our latest data from clinical trials using our autologous BCMA CAR-T product family to treat patients with autoimmunity

10:00 am mRNA Therapeutics: Riding the Next Wave in Biotech

Aalok Shah

Director of Process Development, Resilience

mRNA Therapeutics: Riding the Next Wave in Biotech
Eras that define the evolution of biotechnology
The latest and the greatest in the world of mRNA – the next frontier in biotech
The bottlenecks in clinical translation and how Resilience is striving to address those challenges

10:30 am Morning Networking Break

Day One Track A, AM

Day One Track A, AM, Heading 1

8:00 am Session 1 Day One Track A, AM

Emily Carter

Chief Financial Officer, Global Dynamics

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9:00 am Session 2 Day One Track A, AM

Marcus Johnson

Senior Project Manager, Innovative Solutions

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Day One Track B, AM

Day One Track B, AM, Heading 1

8:00 am Session 1 Day One Track B, AM

Kevin Nguyen

Head of Business Development, Pacific Partnerships

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9:00 am Session 2 Day One Track B, AM

Angela Harris

Director of Marketing, Synergy Strategies

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Discovery Translation Clinical Development CMC

Discovery

Unlocking the Power of Next Generation Base Editors & Replicating mRNA for Pushing the Frontiers of mRNA

11:30 am Advancing Next Generation Gene Editing with Beam Therapeutics’ Proprietary Next Generation Base Editor

Luis Barrera

Senior Vice President, Data Sciences, Beam Therapeutics

Using mRNA for targeted delivery of a single nucleotide base editor to cure genetic ailments
Preventing dsDNA breaks for more efficient and predictable gene editing
Revealing pre-clinical data on ex vivo and in vivo p

12:00 pm Multimodal Support of mRNA Therapeutic Development

Wayne Doyle

Head of Platform, Eclipsebio

12:30 pm Enabling Single-Dose, Multivalent Vaccination Against Pathogens of High Consequence Using a Muscle-Localizing NanocarrierFormulated Replicating mRNA

Jesse Erasmus

Director, Virology, HDT Bio

1:00 pm Accessing a Vast Design Space with a Modular High Throughput Platform for RNA Therapeutics & Vaccines

Stephanie Khan

Director, Business Development, Ginkgo Bioworks

1:10 pm Lunch Networking Break

Advancing RNA Drug Development & Design with Next-Generation Discovery Platforms

2:15 pm Introduction to Orna’s Proprietary IRES Discovery & Drug Design Platform for Durable & Sustainable circRNA Expression

Allen Horhota

Head of Platform, Orna Therapeutics

2:45 pm Novel Efficient Cap Analogs Development & Application for mRNA Therapeutics

Junlan Ren

Co-Founder, Henovcom

Download the event guide for full session details.

3:45 pm Afternoon Networking Break & Poster Session

Advancing Next Generation mRNA Drug Development with Optimized mRNA-LNP Platforms to Enable Targeted Delivery

4:30 pm Introducing ZipCode Bio’s Proprietary mRNA Medicine Platform

Jason Zhang

Co-Founder & Chief Executive Officer, Zipcode Bio

Download the event guide for full session details.

5:00 pm Shedding Light on dsRNA: Specific & Sensitive Detection Using Bioluminescence

Jamison Grailer

Senior Research Scientist, Promega

Download the event guide for full session details.

Translation

Widening the Scope of mRNA with circRNA Vaccines & Therapeutics to Treat Infectious & Oncological Diseases

11:30 am Introducing Orbital’s circRNA Vaccine Platform as a Novel Alternative to a Linear Vaccine

Gilles Besin

Chief Scientific Officer, Orbital Therapeutics

Download the full event guide for full details.

12:00 pm Reduction of LNP-Associated Inflammation with Use of Biodegradable Lipids

Syed Reza

Scientific & Sales Consultant, NOF CORPORATION

Ionizable lipids are known to present varying degrees of immunotoxicity. Understanding the role of key cellular mediators such as the NLRP3 inflammasome in this context will be key to developing
the next generation of safe, well tolerated non-viral delivery systems
Our work on biodegradable ionizable lipids has indicated that tissue resident macrophages are key mediators of immunogenic responses and that the in vivo activity was dependent on the STING pathway
An improved series of biodegradable ionizable lipids has been developed to improve cytokine expression profile and increase Type I interferon levels while minimizing pyrogenic cytokines. Applications of LNP vaccine technology for tumor immunotherapy and infectious disease will be presented.

12:30 pm In vivo panCARTM Therapy Using Circular RNA for the Treatment of B Cell Malignancies in Oncology & Autoimmune Disease

Robert Mabry

Chief Scientific Officer, Orna Therapeutics

1:10 pm Lunch Networking Break

Supercharging the Translation of Novel mRNA Therapeutics to Combat Cancer & Advance Regenerative Medicine

2:15 pm Advancing Novel mRNA Therapeutics Through Discovery & Development Phases

Sam Deutsch

Chief Scientific Officer, Nutcracker Therapeutics

Download the event guide for full session details.

2:45 pm mRNA-Based Transcription Factor Delivery to In Vivo Disease Models

Hanae Toyonoga

Manager, Discovery Accelerator, Astellas Pharma

Download the event guide for full session details.

3:15 pm Advancing Onco-Selective mRNA Therapeutics with Kernal’s KR-335 Program to Kill Tumor Cells

Manfred Kraus

Vice-President, Head of R&D Therapeutics, Kernal Biologics

Download the event guide for full session details.

3:45 pm Afternoon Networking Break & Poster Session

Broadening the Horizons of mRNA Through Next Generation Replicating Vaccines & Therapeutics

4:30 pm Improvements to the Self-AAmplifying RNA Platform for Safer & More Effective Vaccines & Therapeutics

Peter Berglund

Chief Scientific Officer, HDT Bio

Download the event guide for full session details.

5:00 pm Presenting Johnson & Johnson’s Discovery & Pre-Clinical Work with saRNA for Vaccine & Therapeutic Applications

Rachel Groppo

Director, Lead Self-Amplifying RNA Team, Johnson & Johnson Innovative Medicine

Download the event guide for full session details.

Clinical Development

Advancing Neoantigen-Based mRNA Medicines in the Clinic to Effectively Treat Oncological Indications

11:30 am Revealing Key Clinical Findings from Moderna’s Individualized Neoantigen Therapy Against Melanoma

Laureen Ojalvo

Executive Medical Director, Oncology , Moderna

12:00 pm Mitigating Risk Through Development & Engineering Runs When Transitioning from Preclinical to Clinical Manufacturing

Evan Myers

Associate Director, Process Development, TriLink BioTechnologies

12:30 pm Neoantigen Immunotherapy for Solid Tumors: Molecular Responses & Clinical Benefit in Late-Stage Patients

Andy Ferguson

Vice President, Clinical Science, Gritstone Bio

1:10 pm Lunch Networking Break

Supercharging the saRNA Vaccine Platforms Against Infectious Diseases to Improve Patient Outcomes

2:15 pm Next Generation Self-Replicating RNA (srRNA) Drives Substantial Improvement in Infectious Disease Vaccines

Nathaniel Wang

Chief Executive Officer, Replicate Bioscience

Download the event guide for full session details.

2:45 pm Strategies for Navigating the Complexity & Diversity of RNALipid Nanoparticles

Ian Johnston

Field Application Scientist, Cytiva

Download the event guide for full session details.

3:15 pm Comparing a Second-Generation saRNA Flu Vaccine with a Traditional mRNA Flu Vaccine

Cheng Chang

Associate Director, RNA Platform, CSL

Download the event guide for full session details.

3:45 pm Afternoon Networking Break & Poster Session

Revealing the Latest Next Generation Infectious Disease Vaccines to Open Up New Frontiers for mRNA

4:30 pm Beyond Respiratory mRNA Vaccines: Moderna’s Norovirus mRNA Vaccine Candidates

Till Schoofs

Director, Clinical Development, Infectious Diseases, Moderna

Download the event guide for full session details.

5:00 pm Diving into the Analytical Characterization of in vitro Transcribed mRNAs

Julien Camperi, Ph.D.

Technical Development Principal Scientist - Gene & Cell Therapy, Genentech, A Member of the Roche Group

Download the event guide for full session details.

CMC

Developing a Strategic Platform Approach to Ensure Robust Manufacturing Processes for mRNA-Based Drugs

11:30 am Establishing an mRNA Vaccine Platform to Effectively Support a Broad Vaccine & Therapeutics Drug Portfolio

Joshua DiNapoli

Global Project Head, mRNA Platform Development, Sanofi

12:00 pm Trehalose & Sucrose: Essential Components of Platform Biopharma Formulations & COVID-19 Applications

Sudhakar Voruganti

Business Development Director, Pfanstiehl

12:30 pm Leveraging Historic Know-How to Establish a Strategic Internal End-to-End Nucleic Acid Production Platform

Emily Wen

Senior Principal Scientist, Merck & Co

1:00 pm Quality in mRNA Therapeutics – How to Achieve this in Practice

Philip Challis

Senior Vice President of Manufacturing, etehrna

1:10 pm Lunch Networking Break

Mission Possible: Showcasing Breakthrough mRNA Vaccine Initiatives to Establish Rapid Responses to Viral Pathogens

2:15 pm RNA Vaccine Innovations for CEPI’s 100 Days Mission

Dimki Patel

CMC Program Leader, CEPI

Download the event guide for full session details.

2:45 pm Maximizing Success in mRNA Manufacturing: Key Considerations for Analytical Characterization

Eunseo Ency Lee

Lead Scientist, mRNA Manufacturing Group, Samsung Biologics

Download the event guide for full session details.

3:15 pm BAXERNA: On a Mission to Develop Novel Bacterial mRNA Vaccines

Lyudmila Kovalchuke

Project Manager, VIB-UGent

Download the event guide for full session details.

3:45 pm Afternoon Networking Break & Poster Session

Flash Poster Presentations

4:30 pm Flash Poster Presentations

Jeffrey Ulmer, President, TechImmune LLC
Rachel Young, Graduate Research Fellow, Rowan University

Download the event guide for full session details.

Fine-Tuning mRNA Production with Innovative Enzymes & Raw Materials for Faster Synthesis

5:00 pm Democratizing mRNA Therapeutics with Novel Cap Analogs & Modified NTPs

May Guo

Chief Commercial Officer, Areterna

Download the event guide for full session details.

Day One Track A, PM

Day One Track A, PM, Heading 1

2:00 pm Session 1 Day One Track A, PM

David Richardson

SEO Influencer, Search Ltd

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3:00 pm Session 2 Day One Track A, PM

Kevin Nguyen

Head of Business Development, Pacific Partnerships

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Day One Track A, PM

Day One Track A, PM, Heading 1

2:00 pm Session 1 Day One Track A, PM

David Richardson

SEO Influencer, Search Ltd

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3:00 pm Session 2 Day One Track A, PM

Kevin Nguyen

Head of Business Development, Pacific Partnerships

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Day One Track B, PM

Day One Track B, PM, Heading 1

2:00 pm Session 1 Day One Track B, PM

Jenny Maddison

Founder, Avacado Limited

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3:00 pm Session 2 Day One Track B, PM

Harold Johnson

CEO, Acme Ltd

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Day One

Explore the Agenda

7:15 am Morning Check-in & Coffee

8:15 am Chair’s Opening Remarks

8:30 am CXOs’ Panel Discussion: Unlocking the Next Frontiers of mRNA-Based Vaccines & Therapeutics to Ensure Better Drugs Reach Patients Faster

9:30 am Clinical Safety & Impact of RNA Cell Therapy in Patients with Myasthenia Gravis

10:00 am mRNA Therapeutics: Riding the Next Wave in Biotech

10:30 am Morning Networking Break

Day One Track A, AM

Day One Track A, AM, Heading 1

8:00 am Session 1 Day One Track A, AM

9:00 am Session 2 Day One Track A, AM

Day One Track B, AM

Day One Track B, AM, Heading 1

8:00 am Session 1 Day One Track B, AM

9:00 am Session 2 Day One Track B, AM

Unlocking the Power of Next Generation Base Editors & Replicating mRNA for Pushing the Frontiers of mRNA

11:30 am Advancing Next Generation Gene Editing with Beam Therapeutics’ Proprietary Next Generation Base Editor

12:00 pm Multimodal Support of mRNA Therapeutic Development

12:30 pm Enabling Single-Dose, Multivalent Vaccination Against Pathogens of High Consequence Using a Muscle-Localizing NanocarrierFormulated Replicating mRNA

1:00 pm Accessing a Vast Design Space with a Modular High Throughput Platform for RNA Therapeutics & Vaccines

1:10 pm Lunch Networking Break

Advancing RNA Drug Development & Design with Next-Generation Discovery Platforms

2:15 pm Introduction to Orna’s Proprietary IRES Discovery & Drug Design Platform for Durable & Sustainable circRNA Expression

2:45 pm Novel Efficient Cap Analogs Development & Application for mRNA Therapeutics

3:45 pm Afternoon Networking Break & Poster Session

Advancing Next Generation mRNA Drug Development with Optimized mRNA-LNP Platforms to Enable Targeted Delivery

4:30 pm Introducing ZipCode Bio’s Proprietary mRNA Medicine Platform

5:00 pm Shedding Light on dsRNA: Specific & Sensitive Detection Using Bioluminescence

Day One Track A, PM

Day One Track A, PM, Heading 1

2:00 pm Session 1 Day One Track A, PM

3:00 pm Session 2 Day One Track A, PM

Day One Track A, PM

Day One Track A, PM, Heading 1

2:00 pm Session 1 Day One Track A, PM

3:00 pm Session 2 Day One Track A, PM

Day One Track B, PM

Day One Track B, PM, Heading 1

2:00 pm Session 1 Day One Track B, PM

3:00 pm Session 2 Day One Track B, PM

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