Reduction of LNP-Associated Inflammation with Use of Biodegradable Lipids
- Ionizable lipids are known to present varying degrees of immunotoxicity. Understanding the role of key cellular mediators such as the NLRP3 inflammasome in this context will be key to developing
the next generation of safe, well tolerated non-viral delivery systems - Our work on biodegradable ionizable lipids has indicated that tissue resident macrophages are key mediators of immunogenic responses and that the in vivo activity was dependent on the STING pathway
- An improved series of biodegradable ionizable lipids has been developed to improve cytokine expression profile and increase Type I interferon levels while minimizing pyrogenic cytokines. Applications of LNP vaccine technology for tumor immunotherapy and infectious disease will be presented.