Divakara Uppu
Seminars
Thursday 2nd January 2025
TFF in RNA Workflow: Process Optimization for mRNA, saRNA, & LNP Manufacturing
9:00 am
- Delta regenerated cellulose flat sheet membranes with 100 kDa molecular weight cutoff for TFF in RNA workflows
- TFF optimization for mRNA, saRNA, and LNPs where a single filter can work across modalities
- How process conditions can impact LNP processing time
- Scalability data from bench (93 cm2 ) to manufacturing-scale (2.5 m2 ) using LNPs, discussing proper scaling factors
