Tomas Kostelec
Seminars
Thursday 2nd January 2025
Robust mRNA Production with End-to-End In-Process Analytics
3:45 pm
- Design of an efficient multi-step chromatographic process using CIMmultus re-usable columns to achieve scalable production of safe mRNA drug substance with low dsRNA, low fragments and residual DNA
- Deployment of fast analytical methods based on PATfix to reduce cost of drug substance production, and to optimize production and purification processes in shorter development timelines
- Overcoming challenges of in-process LNP drug product characterization by automated analysis of LNP quality attributes with minimal material handling
